M&T Bank’s acquisition of Bridgeport-based People’s United Bank will result in nearly 750 layoffs in Connecticut that will begin in October and continue for the next seven months, according to a notice filed with the state of Connecticut.

The layoffs will affect staff at 15 locations in Connecticut and two employees who work remotely. A total of 747 employees will be laid off in the state, including 661 from the bank’s main office in Bridgeport.

M&T Bank notified the Connecticut Department of Labor of the job losses last week through a Worker Adjustment and Retraining Notification (WARN) Act filing. Christopher Faulkner, M&T’s group vice president and direction of employee relations, said in the notification that the first termination was expected on Oct. 1, with the remaining jobs ending by May 20, 2022.

Darren King, M&T’s chief financial officer, said in an earnings call last week that the bank was on track to receive regulatory approval for the deal and complete the transaction in the fourth quarter.

The second-largest number of layoffs will be at the bank’s Hartford office on Asylum Street in Goodwin Square, the former headquarters of United Bank, which was acquired by People’s United in November 2019. Another employee will also be laid off from the Hartford branch at One Financial Plaza.

Other job losses include eight at a branch on Enfield Street in Enfield, one of three People’s United branches in that town; six at the bank’s Wethersfield location; and five at the branch on Ellington Road in South Windsor, where the bank has three locations.

Other locations losing staff include Cos Cob, East Windsor, New Haven, North Haven, Southington, Stamford and Woodbridge. Two offices in Farmington will also see layoffs.

Gov. Ned Lamont’s office called word of the job cuts disappointing for Bridgeport and the state.

“The governor and his administration will remain in contact with all parties to further minimize job loss and ensure the bank fosters a true partnership with the city of Bridgeport and has a presence in Bridgeport’s communities,” Lamont’s office said in a statement.

An M&T statement said Bridgeport would house the Northeast regional headquarters of the merged bank. It said 79 percent of People’s United employees would keep their jobs following the acquisition, including branch and customer service employees.

The Associated Press contributed to this report.